Phase 1 - Pre-Clerkship Modules

Foundations Block

Molecular, Cellular and Genomic Foundations (Duration: 6 weeks)

This foundational module provides medical students with a comprehensive understanding of the molecular, cellular, and genomic principles that underpin human health and disease. Emphasizing the integration of basic science with clinical practice, the curriculum covers the structure and function of genes, proteins, and cells, biochemical pathways in metabolism, mechanisms of genetic inheritance, and the application of genomic technologies to medicine.

Anatomy (Duration: 6 weeks)

This foundational module offers a comprehensive exploration of the human body's structure, from the microscopic to the macroscopic level. Through detailed study of anatomical regions, organ systems, and the developmental processes that lead to their formation, students will gain a profound understanding of the body's architecture and its functional implications. Incorporating hands-on dissection, microscopic analysis, and clinical case studies, the module aims to bridge the gap between theoretical knowledge and its practical application in medicine. This foundational understanding is critical for diagnosing diseases, performing clinical procedures, and appreciating the intricate relationships that sustain human health and function.

Immunology and Microbiology (Duration: 5 weeks)

This foundational module is designed to provide medical students with an in-depth understanding of the immune system and the microbial world, including bacteria, viruses, fungi, and parasites. This module integrates the study of the mechanisms of immune response, pathogen biology, infection processes, and the principles of vaccines and antimicrobial therapies. Through lectures and case-based learning, students will explore the dynamic interplay between pathogens and the host immune system, gaining insights into disease pathogenesis, diagnostic microbiology, and the current challenges in infectious disease medicine. Emphasizing both the immune system's protective roles and its involvement in disease, this module prepares students for clinical problem-solving and informed decision-making in medical practice.

Pathology (Duration: 3 weeks)

This foundational module is structured to provide medical students with a fundamental understanding of the nature, causes, and development of disease processes. Bridging basic science and clinical practice, the module covers general and systemic pathology, focusing on the alterations in cells, tissues, and organs that lead to disease. Through a combination of lectures, laboratory work, and case studies, students will learn to correlate pathophysiological mechanisms with clinical manifestations, enhancing their diagnostic skills and therapeutic understanding. The module aims to develop a comprehensive understanding of the molecular, genetic, and environmental factors contributing to disease, preparing students for informed clinical decision-making and patient care.

Integrated Systems-Based Content Modules

The modules in the Foundations block are followed by a sequence of integrated pathophysiology systems-based modules. Integrated within each system-module are relevant content in anatomy, physiology embryology, and histopathology. The 10 organ systems-based modules that follow the Foundations block in Pre-Clerkship Phase of ASCEND:

Neuroscience (Duration: 6.5 Weeks)

This organ system-based module provides an integrated approach to understanding the structure, function, and pathology of the nervous system. Students will explore the complexities of the central and peripheral nervous systems, from the cellular and molecular basis of neural function to the behavioral outcomes of neural processes. This module covers key topics such as neuroanatomy, neurophysiology, neuropharmacology, and the neural basis of cognition and behavior, alongside common neurological disorders. The module aims to equip students with the knowledge and skills necessary to localize, diagnose and manage neurological conditions, understand the principles of neurological treatments, and appreciate the impact of neuroscience research on medical practice.

Behavioral Science (Duration: 1.5 Weeks)

This organ system-based module is aimed at understanding the psychological, social, and biological factors influencing health, illness, and healthcare delivery. It combines principles from psychology, sociology, anthropology, and neuroscience to provide students with a comprehensive understanding of human behavior in the context of health and disease. Students will explore topics such as patient behavior, healthcare provider interactions, the impact of social determinants on health outcomes, stress and coping mechanisms, and the psychological aspects of illness and treatment. This module prepares students to incorporate behavioral science insights into clinical practice, enhancing patient care, communication, and treatment compliance.

Hematology (Duration: 3 Weeks)

This organ system-based module is an in-depth exploration of the blood system and its disorders. It combines theoretical knowledge with practical applications, offering students a comprehensive understanding of hematopoiesis, the physiology of blood cells, hemostasis, and the pathophysiology of hematological diseases. Students will learn to recognize, diagnose, treat, and manage a wide range of blood disorders, including anemias, bleeding and thrombotic disorders, hematologic malignancies, and transfusion medicine. This module emphasizes the integration of clinical findings with laboratory data, enhancing decision-making skills and preparing students for patient care in a clinical setting.

Cardiology (Duration: 5 Weeks)

This organ system-based module offers a comprehensive overview of cardiovascular medicine. This module combines theoretical knowledge with practical skills to understand the heart and vascular system's structure, function, and pathology. Students will explore a wide range of topics, including cardiac anatomy, electrophysiology, hemodynamics, common cardiovascular diseases (such as coronary artery disease, hypertension, heart failure, and arrhythmias), diagnostic methods, and therapeutic interventions. This module aims to equip students with the necessary tools to assess, diagnose, and manage cardiovascular conditions effectively, integrating evidence-based practices and the latest research findings into patient care.

Pulmonary Medicine (Duration: 4 Weeks)

This organ system-based module is designed to immerse medical students in the comprehensive study of respiratory system structure, function and diseases with a focus on their pathophysiology, diagnosis, and management. The module covers a broad spectrum of topics, including the anatomy and physiology of the respiratory system, common pulmonary diseases such as asthma, COPD, obstructive sleep apnea, diffuse parenchymal lung diseases, pneumonia, pulmonary embolism, and lung cancer, as well as advanced concepts in pulmonary diagnostics and therapeutics. Emphasizing a patient-centered approach, the module aims to equip students with the skills necessary for effective clinical assessment, evidence-based management strategies, and the delivery of compassionate care to patients with respiratory conditions.

Endocrinology (Duration: 4 Weeks)

This organ system-based module offers a detailed exploration of the endocrine system's structure, function, and the pathophysiology of its disorders. Students will study hormonal regulation and its impact on homeostasis, growth, metabolism, and reproduction, alongside the diagnosis and management of common endocrine disorders such as diabetes mellitus, thyroid diseases, adrenal disorders, and pituitary abnormalities. Emphasizing evidence-based approaches, the module aims to equip students with the competencies necessary for the effective treatment of endocrine diseases, fostering skills in patient education, and encouraging ongoing research engagement.

Gastroenterology (Duration: 5 Weeks)

This organ system-based module offers an in-depth understanding of the gastrointestinal (GI) system's anatomy, physiology, and the wide array of disorders affecting it. Students will delve into the diagnosis, treatment, and management of common and complex GI diseases, such as peptic ulcer disease, inflammatory bowel diseases (IBD), gastroesophageal reflux disease (GERD), and hepatobiliary disorders. Emphasizing a holistic approach, the module aims to equip students with the necessary skills to evaluate and manage GI conditions effectively, integrating nutritional management, pharmacotherapy, and endoscopic techniques, while also considering the psychosocial and societal aspects of chronic GI illnesses.

Genitourinary, Sexual and Reproductive Health (Duration: 4 Weeks)

This organ system-based module offers a comprehensive examination of the anatomy, physiology, and pathology of the genitourinary system, along with critical aspects of sexual and reproductive health. The module explores a wide range of topics, including urinary system diseases, sexual health, reproductive endocrinology, infertility, and common disorders of the genital system. This module emphasizes a holistic and patient-centered approach to diagnosing, treating, and managing genitourinary and reproductive health issues, incorporating the latest evidence-based practices and technologies. It aims to prepare medical students with the knowledge and skills necessary to provide sensitive, informed, and comprehensive healthcare services in these areas, focusing on the impact of such conditions on individuals and populations.

Renal (Duration: 4 Weeks)

This organ system-based module covers an in-depth understanding of kidney function, the pathophysiology of renal diseases, and their management. It covers key topics including renal anatomy, histology, physiology, pharmacology, as well as fluid and electrolyte balance, acid-base disorders, glomerular diseases, genetic and tubulointerstitial diseases, acute kidney injury (AKI), chronic kidney disease (CKD), glomerulonephritis, and renal replacement therapies. This module emphasizes a holistic approach to patient care, focusing on early detection, prevention strategies, and the latest treatment modalities for renal diseases. It aims to equip students with the knowledge and clinical skills necessary to provide comprehensive care to patients with renal conditions, advocating for patient education and empowerment in managing their health.

Musculoskeletal Pathophysiology (Duration: 3 weeks)

This organ system-based module provides an in-depth understanding of the anatomy, physiology, and pathology of the musculoskeletal system. This comprehensive module covers the structure and function of bones, muscles, joints, and connective tissues, along with the common disorders that affect these components, such as fractures, arthritis, muscular dystrophies, soft tissue injuries, and bone tumors. Students will learn to assess, diagnose, and manage musculoskeletal conditions, integrating pharmacological, surgical, and rehabilitative treatment strategies. Emphasizing a holistic approach, the module aims to equip students with the knowledge and skills necessary for effective patient care in orthopedics and related fields, fostering an understanding of the impact of musculoskeletal health on overall well-being.

Practice of Medicine

The longitudinal Practice of Medicine (POM) module is designed to integrate theoretical knowledge with essential clinical skills early in medical education. This module systematically develops students' abilities in patient assessment, history taking, physical examination, communication, and ethical decision-making, laying the groundwork for their future clinical practice. Through interactive workshops, simulated patient encounters, and reflective practice, students will begin to cultivate the core competencies necessary for patient care. The module emphasizes the importance of professionalism, patient-centered communication, and the basics of clinical reasoning, preparing students for their subsequent clinical rotations and fostering a lifelong commitment to excellence in medicine.

Embedded in POM will be early clinical exposures through the longitudinal POM module with exposures to patient care in simulated and standardized patient experiences as well as ambulatory, acute inpatient, and emergency room settings. A hallmark of ASCEND is its "whole patient" approach, encompassing a vast spectrum of patient experiences from caregiver dynamics to societal factors. This comprehensive design prepares students not only for USMLE licensure examinations but also for the multifaceted demands of contemporary medical practice.

Students will be introduced in POM to their clinical competency mentoring microsystems who will guide them in acquiring clinical skills required in the clerkships. The Clinical Competency Mentoring Program with their longitudinal Clinical Competency Mentors (CCMs), utilizes first-hand observations to provide insightful and timely feedback for the mentees' development, thereby enhancing the learning experience.